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The main focus of the work is an introduction of modifications that provides collision-free navigation in environments with moving obstacles.
However, Popper later came to recognize that the introduction of modifications (immunizations, he called them) was often an important part of scientific development.
This fact also justifies the introduction of modifications in the RTOG scale (Hanlon et al, 1997).
This, however, means that there are more chances for the introduction of modifications of the model.
Use of covalent labeling (surface mapping) approaches requires consideration of whether the introduction of modifications can alter the structure of the analytes.
The use of covalent labeling approaches requires consideration of whether the introduction of modifications alter the structure of the analytes; therefore, checking the structural integrity of the protein subjected to covalent labeling is essential.
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In the majority of the studies, the most efficient introduction of modification was observed in the nearest vicinity of the binding site of the targeting domain (10 40 bp [ 98, 102, 123]), which is in line with the typical distance that the linker region between the DBD and effector domain can provide.
Importantly, these noncognate enzymes enabled us to change the pattern of PTMs, leading to the introduction of unnatural modifications in vitro.
Moreover, the introduction of genetic modifications into future generations could have permanent and possibly harmful effects on the species.
The introduction of chemical modifications in quadruplex structures could enhance the in vivo biological activity.
Introduction of these modifications into the quantum-mechanical formulation of the crystal field theory improves the agreement of its quantitative predictions with experimental observations.
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