With the introduction of mechanism-based or 'targeted' therapies in oncology, there is a need to develop biomarkers to prioritise new agent development (predictive and prognostic), optimise dosing schedules (pharmacodynamics, PD), and rationalise combination selection (Tan et al, 2009; Cummings et al, 2010).
Introduction of mechanisms for prioritisation would improve the program [ 36].
We also support the introduction of mechanisms to improve provider accountability and regular institutional perinatal audit.
Łódź, being a typical industrial city, had to confront serious problems after the year 1989, i.e. a period of social and economic change and the introduction of mechanisms of market economy [ 22].
Morgan said this introduction of a mechanism to "ratchet up" targets might be the most important paragraph of the document and was "fundamental to keeping 2C within sight".
Considering that the premise variables of the fuzzy diagnostic observer and the system may belong to different local space regions due to the introduction of ET mechanism, a partition method-based piecewise fuzzy diagnostic observer is designed to detect faults.
The score on revenue and risk criteria is also high with regard to Scenario 1. Group A appears to associate more the introduction of TIF mechanism with potential political cost, whereas at the same time the lack of experience on this specific financing tool seem to worry them more, comparing to the other two scenarios.
This allows also the introduction of ratchet mechanism to allow locking the forceps closure and relative release buttons, shown in Figure 12.
With impeccable logic, Robert Jackson explained that his brand of Conservatism, especially his belief in the introduction of market mechanisms into the provision of public services, was now being delivered more effectively by Tony Blair than by Michael Howard.
The nonchalance with which he proclaims this ideological U-turn is reminiscent of the way officials in neighbouring China began justifying the introduction of market mechanisms in the 1980s.Farmers' markets seem to have played a role in North Korea's change of tack.
The introduction of incentive mechanisms in cooperative networks has attracted attention in the literature [5 14].
