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The synthetic approach was designed to allow the introduction of functionality at the central core of the inhibitors, which should enable the identification of small molecule inhibitors of diverse aspartyl protease targets.
Despite this shortcoming, the Saegusa oxidation has been used in a number of syntheses as a mild, late-stage method for introduction of functionality in complex molecules.
In addition to the introduction of functionality to these aminomaleimide fluorophores through choice of the amine substituent, further functionality can also be easily incorporated at the maleimide nitrogen.
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Recent developments on the introduction of functionalities based on encapsulation of corrosion inhibitors, anti-fouling agents and superhydrophobic additives or modification of organic and hybrid matrices via chemical manipulation are reviewed.
Further, introduction of tertiary/quaternary functionality increases their cellular uptake.
This results in an amplification of the surface area and an introduction of catalytic functionality, while the favorable mass transfer properties of the porous support are retained.
An SDN-enabled network facilitates the introduction of ICN functionality, without requiring a complex transition strategy and the re-deployment of new ICN capable hardware.
These results demonstrate that introduction of chemical functionality into Fmoc-peptide scaffolds may provide gels with tunable chemical and mechanical properties for in vitro cell culture.
In this paper we investigate whether the introduction of chemical functionality, such as NH2, COOH or OH, enhances compatibility with different cell types.
The successful introduction of surface functionality was proved by Fourier transform infrared (FTIR; Figure 3), showed the infrared spectrometric waveforms of two sample groups are similar and the main peak positions of the graph are identical.
However, among the various functionalizations, the epoxidation of unsaturated –C=C– bond at mild reaction condition is a wonderful synthetic tool for introduction of versatile functionality to the rubber chain.
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