Sentence examples for introduction of a termination from inspiring English sources

This deletion causes a frameshift resulting in the introduction of a termination codon in exon 679.

Furthermore, the three patients had additional RNA species associated with the c.48G>A allele, in which various portions of the 5′ region of intron 1 were retained, resulting in the introduction of a termination codon, 26 codons beyond exon 1.

Open reading frame (ORF) analysis predicts that omission of the 187-nt exon 3 introduces an in-frame premature termination codon, UAA in exon 4. Introduction of a premature termination codon in the exon 4 is predicted to create a short ORF, encoding a C-terminal truncated peptide of 80 amino acids (Figure S5, see ORF1).

ORF analysis predicts that omission of the 187-nt exon 3 results in the introduction of a premature termination codon in exon 4 creating a C-terminal truncated protein of 80 amino acids.

This resulted in a total of 300 shared heterozygous variants, which were narrowed down to 11 by selecting variants that result in nonsynonymous amino acid changes, the introduction of a premature termination codon, frameshifts, or (predicted) splice sites changes with an allele frequency below 0.1 in dbSNP137.

The disease is recessively inherited and caused by a deep intronic, single base transition in the iron sulfur cluster scaffold, ISCU gene that causes retention of a pseudoexon and introduction of a premature termination codon.

For example, the mouse Q10 gene contains a 13 bp deletion in the exon encoding the Tm domain, causing a frame shift and the introduction of a premature termination signal downstream in the same exon.

The p.Q322RfsX13 (c.964delC) frameshift mutation is a single-base deletion which results in the introduction of a premature termination codon.

An analysis of the exon/intron junction of these 2 HbJAZs showed that this splicing led to the introduction of a premature termination codon (PTC).

In Ws-4 this SNP is predicted to create a new splicing branchpoint sequence that induces a partial mis-splicing of the pre-mRNA, leading to the introduction of a Premature Termination Codon.

Given that the variant occurs after the first (coding) exon of Areg, we predicted that Areg Mcub would lead to intronic read-through, introduction of a premature termination codon in exon 2, and ultimately to nonsense-mediated decay (Fig. 1C).