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The metabolites detected in this study that do correlate with the duration of hypoxia might help in the clinical setting for either introducing therapy at an early stage or for risk stratification and close surveillance by other methods like amplitude integrated electroencephalography (aEEG) [42], [43].
It has been suggested that introducing therapy with a non-anti-TNF mechanism of action may provide greater benefit than a subsequent anti-TNF medication [ 27].
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All of these disasters have the common underlying cause of introducing therapies into the care of the most fragile of patients without adequate investigation of their potential harm.
There have been laudable efforts on the parts of activists like Lord Layard to introduce therapy into the NHS, but progress is slow and vulnerable.
Dutasteride, a dual 5-alfa-reductase (5AR) inhibitor (5ARI), is a recently introduced therapy for the treatment of BPH.
As adenoviral constructs typically can be transcribed but not replicated with cell division, it was important to predict the length of time the introduced therapy might be effective.
The logical response to this was to introduce therapies which increase cardiac output, with the aim to overcome relative hypoperfusion and therefore improve patients' outcomes [35 37].
In patients with certain genetic subsets of melanoma, recently introduced therapies such as BRAF inhibitors improve survival, even in advanced disease (Chapman et al, 2011; Hauschild et al, 2012; Flaherty et al, 2012b).
The need to monitor side effects of treatment, especially in relation to some of the more recently introduced therapies such as aromatase inhibitors (bone health) and trastuzumab (cardiac toxicity), was another important reason for maintaining longer follow-up.
The number of dogs admitted or returned to rescue shelters with behaviour problems may be reduced by raising public awareness regarding the value of behaviour therapy and introducing behaviour therapy schemes to rescue shelters.
This is relevant for clinical decisions regarding management of patients using this therapy and for introducing alternate therapies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com