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Previous studies found that the WTH3 gene was down regulated in MDR cell lines, and by introducing it back into those lines caused down regulation of MDR1 gene expression that reversed their MDR phenotypes to various anti-cancer drugs [ 9, 15].
Previous studies found that the WTH3 gene was downregulated in MDR cell lines, MCF7/AdrR and MES-SA/Dx5 (a human uterine sarcoma cell line), and by introducing it back into those lines caused downregulation of MDR1 gene expression and reversed their MDR phenotypes to various anticancer drugs (Shan et al, 2002a; Tian et al, 2005b).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com