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It has recently been demonstrated that mouse and human fibroblasts can be reprogrammed into an embryonic stem cell-like state by introducing combinations of four transcription factors.
Nonintegrating lentiviral (NIL) vectors were produced from HIV-1-based lentiviral vectors by introducing combinations of mutations made to disable the integrase protein itself and to alter the integrase recognition sequences (att) in the viral LTR.
This leads to a clinically recognisable, well-defined target population for the implementation of new treatment strategies introducing combinations of cytotoxics with antiangiogenic (e.g. anti-VEGF) compounds.
It is known that partner notification and treatment can be improved by introducing combinations of provider and patient referral, and by explicit and thorough verbal health education [ 13].
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74 The local mixture of vector species and their ecologies and behaviors has a tremendous impact on the effect of introduced combinations of interventions, and current efforts to map these species ratios and measure these values are essential to inform planning.
The newly introduced combination of focused ion beam technique with high resolution scanning electron microscopy is the first method to initiate artificial microcracks with idealized crack parameters in front of selected phase- and grain boundaries.
Conversely, to ascertain that the introduced combination of animals is not likely to suffer outbreeding depression.
The newly introduced combination of vsn and loess produced the best result in terms of noise reduction [ 31].
Eflornithine is effective only against T. brucei gambiense infections and is difficult to administer, requiring hospitalization and intravenous infusions every 6 h for 2 weeks (7), although a recently introduced combination therapy of nifurtimox and eflornithine (NECT) has reduced the treatment burden (13).
As such, firm D innovates by introducing new combinations of already regionally known knowledge.
This vaccine system has the added advantage of rapid adaptability to emerging influenza strains by introducing different combinations of hemagglutinin and neuraminidase.
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