We decided to introduce an alteration to our reporter assay in comparison with the original to make it more relevant to address the effect on ongoing translation.
In addition to transmural heterogeneity, intrinsic apicobasal heterogeneity in repolarization was introduced via an alteration of the slow delayed rectifier potassium current IKs.
We started with the already parameterized model without introducing any alterations or adjustments, except for resetting the appropriate enzyme activities, and tested how the system responded to the inhibition in comparison to the in vivo experiments [ 19].
To favor the development of tumors we introduced a second genetic alteration and applied an additional mutagenic noxa.
In other words, introducing vibration induces an alteration of the sensory information that subjects can use for postural control.
The emerging technology of genome editing, also known as genome engineering, seeks to meet this need by providing the ability to more efficiently introduce a variety of genetic alterations, ranging from single-nucleotide modifications to whole gene addition or deletion, all with a high degree of target specificity.
The purpose of this paper is to introduce a control method for the alteration of endoscope direction using pupil-tracking into the Prototype 2 [16] system, which is achieved via image processing and the use of a webcam.
However, these TEs also introduce a large number of deleterious alterations in the host genome.
As a consequence, the possibility that BCG introduces phenotypical alterations of TCC cells that affect tumoricidal effector mechanisms has been a subject of study.
The hypothesis we have been testing here is that H. pylori, and in particular those strains that possess the cag A virulence gene, induces ROS in gastric tissue which subsequently introduces genetic alterations (p53 mutations), which drive gastric cancer progression.
While culturing the cells introduces its own alterations in gene expression, these alterations are uniform across samples.
