Subramaian et al. [5] introduced a hypothesis that focuses on a defective remodeling process secondary to weakened synergism among the key cell types that interact during bone remodeling, including osteoblasts, osteoclasts, osteocytes, and bone lining cells.
Using the concept of self, Burnet introduced a hypothesis about the situation where the body failed to make antibodies to its own components (autoimmunity) and by extension the idea of immune tolerance.
The present study re-introduces a hypothesis of a faecal-oral route of infection being a more prominent feature in Mah than in Maa.
This review attempts to update recent progress in this area and to introduce a hypothesis as to how non-symbiotic haemoglobins might participate in regulating hormone signal transduction.
Here we introduced a hypothesis-generator approach to determine key genes involved in the urothelium/sumbmucosa responses to BCG therapy.
By introducing a hypothesis-testing step, the d derived from Figure 2 now varies systematically with the number of subjects enrolled in the study (and the number of mixtures tested), and with the choice of significance criterion α.
Here we introduce a hypothesis-driven method that integrates bio-molecular network topology with transcriptome data, thereby allowing the identification of key biological features (Reporter Features) around which transcriptional changes are significantly concentrated.
This extensive analysis introduces a provocative hypothesis in the physiopathology of ARF: the traditional mechanism of ischemic ARF in critically ill septic patients is put to discussion and, if confirmed by specifically designed experimental and human studies, it could provide new important information about the prevention and therapy of septic ARF.
The model avoids the use of the fictive temperature, which makes it easier to introduce a different hypothesis on the limit states of the process.
It turns out that this is not quite the end of the story, however, for it is possible to generalize Theorem 2.3 by introducing a suitable hypothesis.
