In patients with certain genetic subsets of melanoma, recently introduced therapies such as BRAF inhibitors improve survival, even in advanced disease (Chapman et al, 2011; Hauschild et al, 2012; Flaherty et al, 2012b).
The need to monitor side effects of treatment, especially in relation to some of the more recently introduced therapies such as aromatase inhibitors (bone health) and trastuzumab (cardiac toxicity), was another important reason for maintaining longer follow-up.
There have been laudable efforts on the parts of activists like Lord Layard to introduce therapy into the NHS, but progress is slow and vulnerable.
San Jose was the first US airport to introduce therapy dogs, shortly after 9/11.
It has been suggested that introducing therapy with a non-anti-TNF mechanism of action may provide greater benefit than a subsequent anti-TNF medication [ 27].
The logical response to this was to introduce therapies which increase cardiac output, with the aim to overcome relative hypoperfusion and therefore improve patients' outcomes [35 37].
All of these disasters have the common underlying cause of introducing therapies into the care of the most fragile of patients without adequate investigation of their potential harm.
Our institution was subsequently involved in a trial of Y-90 edotreotide therapy and introduced LuTate therapy in 2005.
The number of dogs admitted or returned to rescue shelters with behaviour problems may be reduced by raising public awareness regarding the value of behaviour therapy and introducing behaviour therapy schemes to rescue shelters.
