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Next, they designed genetic changes, which can be thought of as software edits, with the aim of introducing specific alterations into the chromosome.
Repair of a ZFN-induced DSB by HR with an appropriately designed exogenous "donor template" (a process known as ZFN-induced gene targeting) has been used to introduce specific alterations or insertions with high efficiencies at endogenous genes in Drosophila [18], [19], plant [Townsend et al, manuscript submitted], and human cells [23] 26, 43.
Such a strategy would require the ability to efficiently introduce specific genetic alterations into the genomes of hPSCs at will.
In turn, Part II introduces specific hypoplastic models for soils.
Oligonucleotide-directed mutagenesis is one of the most popular methods to introduce site-specific alterations into a DNA sequence.
Specific alterations in the nucleotide sequence were introduced by incorporating nucleotide changes into the overlapping oligo primers.
Thus, CsA nephrotoxicity is associated with specific alterations in renal AA metabolism.
Furthermore, we show that the presentation of defined sensory modalities induces specific alterations in reversal behavior and that the AIY interneuron class mediates this alteration in locomotory behavior.
This study identifies novel frequency specific alterations of resting fluctuation of fMRI measured brain activity.
Given their localization, the specific alterations in Cx expression may reflect their distinct response to ambient light levels.
Cancer cells frequently exhibit specific alterations in their metabolic activity.
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