Sentence examples for introduce termination from inspiring English sources

Library diversity is further restricted by NNK and NNN saturations which randomly introduce termination codons that may lead to non-functional proteins, possibly leading to aggregation.

The retention of the intronic sequences introduces termination codons within the mature FIBP mRNA leading to premature termination of translation.

They introduce a termination criterion and terminating algorithms for constraint simplification and improvement.

Instead, due to the nature of CRNs, a new type of forced call termination is introduced: forced termination due to intra-cellular handoff failure triggered by the arrival of a PU.

Polymorphisms not found in cis-regulatory regions can also result in apparent allele-specific splicing if they introduce premature termination codons (PTC) [ 45] and cause differential nonsense-mediated decay of alternative alleles.

Most of the deleterious germline mutations in BRCA2 introduce premature termination codons and trigger nonsense-mediated mRNA decay [ 11].

To make a PTEN construct with deletion of the last six residues (TQITKV), PCR was conducted to introduce premature termination, using pcDNA3.1-PTEN as a template.

These new deletions and an insertion create frameshifts, which are predicted to introduce premature termination codons into the PAX6 reading frame.

One potential drawback to the use of cDNA templates is that nonsense-mediated mRNA decay could potentially decrease the efficiency of identifying ENU-induced mutations that introduce premature termination codons, although this type of mutation will occur infrequently compared to those that cause amino acid substitutions.

C-terminal truncations were created by introducing a termination codon at the appropriate position in the sequence, again using QuikChange™.

Furthermore, we produced an extension domain that corresponds to residues 1 143 of the modified α′ subunit containing four RPLKPW sequences by introducing a termination codon.