It begins as a chorale, sung and played by the orchestra, then repeated, again and again, each repetition introducing subtle changes.
In successive series of paintings, he introduced subtle changes into geometric forms that evolved from circles, chevrons, stripes and diamonds and back again to the circle late in his career.
Chemistry is without doubt most suited for introducing subtle changes into biomolecules down to the atomic level, but often struggles when it comes to large targets, such as proteins.
By introducing subtle changes in the endogenous mouse Rb1 gene (Rb1ΔL), we have previously shown that interactions at the LXCXE binding cleft are necessary for the proper response to anti-growth signals such as DNA damage and TGF-β, with minimal effects on overall development.
Once a ZFN pair, or another targeted nuclease, has been validated for a target within a locus, it can be used to introduce subtle or dramatic sequence changes from a suitably designed donor over long distances, without the need to develop additional cleavage reagents.
But the album also introduces subtle rhythmic changes, and guests, including the singers Djavan and Milton Nascimento and Gilberto Gil, make contributions.
Their smaller size may allow MITEs to introduce more subtle changes in gene expression or regulation, and their high copy number makes their potential impact higher.
The intrinsic complexity of antibody structure, the heterogeneity introduced by subtle changes in product manufacturing, and the potential complications associated with the introduction of biosimilar mAbs to the marketplace must be brought to the forefront of critical discussion.
The choice of conversion method (and converter) is at least as important a decision as the choice of resin for an UHMWPE component because both factors introduce a subtle change in the morphology and material properties of the consolidated polymer.
Might pushing reform too far damage its own interests, by toppling friendly regimes and seeing them replaced by something worse not just worse for America but also, perhaps, for the Arabs themselves?In June 2009 the newly elected President Obama introduced a subtle change in American policy.
