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It is not expected that these differences would introduce substantial bias.
This basic interpolation scheme is straightforward and does not introduce substantial interpolation errors.
However, 5G introduces substantial changes on many levels.
We show that if not corrected, heterochrony introduces substantial biases in population statistics.
No substantial modifications were introduced by subsequent Treaties until the major changes brought by the Treaty of Lisbon.
A splendid one was built at Marāgheh (now in Iran) about 1260 ce, and substantial modifications in Ptolemaic astronomy were introduced there.
Note, however, that after 1997, a sequence of small changes have been progressively introduced (ending in the 2011-2013 reforms, which include quite substantial modifications of the parameters and the working of the system).
Our protocol is based on established methods [22], [3], [4], [7] but substantial modifications to the available rat protocols had to be introduced (Table 2).
For airports, preparing for the A380 requires substantial modifications to runways, taxiways and terminal gates.
Substantial modifications of glacier activity and sedimentation can follow.
A truly plausible case, however, would require substantial modifications of both the argument and the practices associated with that defense.
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