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Therefore, if the framework for how capsaicin activates TRPV1 is correct, one might be able to use it as guidance to introduce sensitivity to capsaicin and other vanilloids into ion channels insensitive to these molecules.
However, introduction of IRS-1 or -2 expression in T47D-YA cells was sufficient to introduce sensitivity to αIR-3, suggesting that expression of appropriate adaptor molecules, in addition to functional receptor, may be necessary to observe a response to therapeutic agents targeting IGF-IR.
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The approach introduces sensitivity analysis for factor fixing, harnessing hourly data and metrics that take into account surface temperatures.
We introduced sensitivity and specificity well-known from other areas of biomedical research to the context of haplotypes and present an analytical computational approach.
Adding or subtracting one base from the interval between the two direct repeats diminishes T3 ligand sensitivity and introduces sensitivity to either retinoic acid (RA) with a 5 nucleotide spacer (DR+5) or Vitamin D3 (VitD3) with a 3 nucleotide spacer (DR+3) [22].
For the introduced sensitivity study, one regional climate model has been applied driven by one emission scenario.
Diaz-Ledezma et al. [ 107] and Diaz-Ledezma and Parvizi [ 73] referred to Erkut and Tarimcilar [ 40], who introduced sensitivity analysis for the AHP.
However, in attempting to correct for this bias, the resampling procedure of the QTLST introduces sensitivity to the variance of the QTL effects, a result which has no basis in the history of neutrality or selection.
We also introduce seed sensitivity and explain the intuitive advantages of multiple seeds.
In addition, efforts have been made to introduce hypoxia sensitivity to the CMV promoter by coupling it to hypoxia response elements (HREs).
Reducing QT-alert overload by excluding drugs without proven risk of causing TdP from alert generation would result in a considerable reduction in alert numbers, would not change the positive predictive value, and would introduce a sensitivity problem.
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