Exact(2)
Shown to work just 3 years ago, CRISPR consists of a an enzyme called a nuclease and a piece of RNA that homes in on a targeted DNA sequence, enabling the enzyme to introduce precisely targeted mutations, corrections to mutations, or other alterations.
The ability to introduce precisely targeted changes at high efficiency has many applications, including introducing human mutations into mouse genes quickly and precisely, and may also find utility in the manipulation of single exon genes where there is a risk of disturbing important flanking sequences by conventional targeting methods, especially if a conditional allele is required.
Similar(58)
The cannulated screw can be introduced precisely over a guide wire and is inserted with a specific screwdriver.
Hence, banks had a big incentive to save on costly equity and circumvent capital requirements which had been introduced precisely to offset such risk-taking behavior by putting assets into off-balance sheet vehicles.
But narrow content was introduced precisely in order to have a kind of content that my Twin and I share, so the narrow content of my thought that the lakes contain water should come out true in a Twin Earth environment centered on my Twin, just as my Twin's parallel thought comes out true there.
An SB-based transposon vector is well suited to accomplish this task by introducing precisely integrated functional reporter units into the mouse genome.
Anyone thinking the challenge to honestly report uncomfortable test results is a trivial or infrequent concern should remember that fit indices were initially introduced precisely to mollify researchers fretting over failing models.
Designer nucleases allow the creation of new plant genotypes by introducing precisely-targeted double-strand breaks that are resolved by endogenous repair pathways.
It is shown that in some cases, a more refined friction law with higher order than quadratic expansion should be introduced to precisely model the dynamic system.
To determine the waiting time for dynamic equilibrium, a preliminary adsorption experiment was carried out which involved introducing a precisely weighed quantity of adsorbent into a volume of 500 mL of solution containing dye at a concentration of 50 mg L−1.
We show that the wollastonite ceramic can be rationally tuned in phase (α or β), mechanical strength (in compression and bending mode), elastic modulus (18 23 GPa), and fracture toughness (>3.2 MPa m1/2) through the usage of Mg dopant introduced at precisely defined dilute concentrations (Mg/Ca molar ratio: 1.2 2.1%).
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Justyna Jupowicz-Kozak
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