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Identification of significant patterns in network traffic, such as IPs or flows that contribute large volume (heavy hitters) or those that introduce large changes of volume (heavy changers), has many applications in accounting and network anomaly detection.
Second, the extraordinary bias toward A+T richness (80%) in nucleotide composition of the parasite, may introduce large changes in both DNA and amino acid sequences which may affect the search procedures.
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Break down the process into smaller and simpler steps and gradually introduce larger changes in small increments.
Moreover, the variation in the tidal level introduces large change in the modeled tsunami impact and, therefore, affects the level of building vulnerability.
Such curves play a useful role in understanding why controlling for ERS introduces larger changes in the mean estimates of the substantive traits for some countries but not others.
Strategies that target mutagenesis to particular regions of a protein or use recombination to introduce large sequence changes can complement full-gene random mutagenesis and pave the way to achieving ever more ambitious enzyme engineering goals.
One source of error could be that the mutations introduce larger conformational changes of the active site, changes which are not properly represented in our calculations because we use the WT crystal structure as a starting point for the mutant calculations.
Due to the significant time to introduce large-scale changes in the utility sector, nuclear energy cannot have a dramatic short-term effect on emissions.
We have introduced large structural changes into Arabidopsis chromosomes and report their effects on crossover positioning.
Rearrangements or large indels introduce large positive terms in the variance calculation of orthologs affected by the changes for the genomes belonging to different subgroups, but the contributions corresponding to the relationship within each subgroup remain zero.
Such small-scale changes on transcription factors in turn can introduce large-scale transcriptome-level changes via downstream target genes.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com