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Indeed, the basic view that nuclear aggregates formed by CUG expansions are intrinsically toxic and/or that toxicity severity is determined only by the size of the repeats and their concentration have been already challenged by various studies [6], [17] [19].
At root is an intrinsically toxic relationship between the three parties to the advertising ecosystem: advertisers, publishers and readers.
The longstanding question as to whether carbon nanotubes are intrinsically toxic hinders their widespread industrial application.
Although carbon is not considered as an intrinsically toxic element, the specific material configurations and structures of C-dots may be potential risks to human health, thereby raising public concern [22].
Administration of 15 mg/kg CpdA to non-immunized mice was also lethal (data not shown), confirming that high-dose CpdA was intrinsically toxic.
This result suggests that 10 mg/Kg CDDO-Im is not intrinsically toxic to mice, and that the mortality of CLL/SBL mice might be related to the effect of the drug on the leukemic cells.
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PMA/PMMA drugs are intrinsically more toxic than MDMA, but are sold as ecstasy.
In this way, the vineyard becomes a self-regulating, natural ecosystem, which is able to combat problems intrinsically and eliminates the need for artificial, and potentially toxic, chemicals.
Toxic exposures often elicit cellular responses that are intrinsically oxidant in that they involve production of reactive oxygen species (ROS) and/or the loss of intracellular reducing potential.
However, to fully understand the challenges of respiration, we need to think beyond oxygen shortages [ 17], because breathing oxygen is intrinsically dangerous: while a shortage quickly leads to suffocation, too much is toxic [ 10, 18].
Intrinsically, its major properties are free radical scavenging and anti-inflammatory, as well as protection against toxic heavy metals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com