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Intrinsically small animals sometimes become large in the same way that protozoans evolved into metazoans: they multiply the number of individuals by asexual reproduction (thus maintaining the same genotype) and remain attached, with the option that individuals can be modified during their development for a specialized function.
The intrinsically small volumes and highly controlled reaction conditions render continuous flow microreactors ideal systems for the synthesis of potentially explosive compounds such as organic azides.
Since the electrochemical signal of salbutamol was intrinsically small, the oxidation peak of the participant Cu2+, after reduction step, was recorded and used as an indication of salbutamol amount, adsorbed in the electrode.
The results illustrate the potential of the bilayer scaffolds to overcome major limitations of conventionally electrospun scaffolds associated with intrinsically small pores, low porosity and, consequently, poor cell infiltration.
More markers may enhance the statistical power of genetic studies and yield more precise estimates of small genetic differentiation values (Patterson et al. 2006), but the signature of dispersal contained in the data may remain intrinsically small or inexistent.
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Since the starting material is very limited and the reaction yield is intrinsically low, even losing a small fraction of the target DNA would potentially compromise sequencing efforts.
High capacity wireless link typically requires high connection setup cost, while wearable devices are intrinsically equipped with small battery.
Pupylation is a post-translational protein modification occurring in actinobacteria through which the small, intrinsically disordered protein Pup (prokaryotic ubiquitin-like protein) is conjugated to lysine residues of proteins, marking them for proteasomal degradation.
A four-step disordered signalling conduit has been recently proposed to explain the functionality of the cyclin-dependent kinase inhibitor p27Kip1 (p27) [ 9]. p27 is a small intrinsically unstructured protein [ 110] regulating cell proliferation through interactions with cyclin-dependent kinases (Cdks) [ 111].
The stochasticity originates intrinsically from the small copy numbers of the molecular species in a cell, which frequently occur when molecular concentrations are in the range of 0.1 μM to 1 nM (typically from about 100 to 10 copies in a cell) [ 2, 6].
Pathways exist for these proteins in which the energy barriers between two positions are relatively small (intrinsically or through the action of chaperones) so that the proteins are able to move rapidly (favorable kinetics) from their initial high-energy unfolded states to their final low-energy natively folded states.
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