A prevailing view was that type II inhibitors are intrinsically more selective than type I inhibitors, which has served to spur many type II medicinal chemistry campaigns.
Using a small library of type II inhibitors, we demonstrate that more than 200 kinases can be targeted, suggesting that type II inhibitors may not be intrinsically more selective than type I inhibitors.
These findings suggested that human iNKT cells can be intrinsically polarized to selective production of IL-13 by maintaining a low level of activation using weak agonists, whereas selective polarization to IL-4 production cannot be achieved through modulating the strength of the activating ligand.
It is shown that certain bulk metal sulfides are intrinsically active and selective for desulfurizing 4-substituted and 4,6-disubstituted dibenzothiophenes.
Relief inversion can occur by a range of processes, including infill of depressions by intrinsically resistant material, selective secondary cementation via diagenesis and weathering, or surface armouring.
On-chip detection is based on resonance-enhanced multiphoton ionization (REMPI) [56], which is quantum state selective, is intrinsically background-free, and is of general applicability.
Ideally, BACE1 inhibitor drugs should be of a molecular weight <500, orally bioavailable, metabolically stable, intrinsically potent, and highly selective for BACE1 over BACE2 and other aspartic proteases.
A cornerstone principle of neurophysiology is the idea that neurons are either intrinsically designed to be selective with respect to the stimuli to which they will respond, or through connections with other units, can be made to be selective [ 1- 4].
At high metal loadings, where the relative population of intrinsically less active and C5+ selective Co0 nanoparticles is decreased, RuCo/Al2O3_nf catalyst displayed the highest cobalt-time-yield and diesel productivity.
Therefore, whether exogenously imposed or intrinsically engineered, DSBs triggered p53 selective activation that was confined to GSCs and their immediate progeny.
