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ELISA-based detection of histone-associated DNA fragments confirmed that trastuzumab-refractory JIMT-1 cells were intrinsically protected against the apoptotic effects of HER1/2 TKIs.
89 Further supporting the idea that OR rats have higher endogenous SPA, we later showed that OR rats are also more sensitive to other SPA-promoting stimuli including caloric restriction 96 and appear to be intrinsically protected from treatments that lower SPA, such as high-fat diet feeding.
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This observation converges on a recent model, which proposed that pluripotency is a ground state that is intrinsically self-maintained when protected from extrinsic differentiation stimuli [ 30].
While these rights are intrinsically intertwined with political and civil rights—rights protected by their own international treaties scholars are urged not forget to fight for economic, social and cultural rights as well.
Otherwise isogenic UNG+/+ cells are largely protected from these effects, suggesting uracil is intrinsically cytotoxic.
The real explanation, I think, is that independent judges see it as intrinsically their duty to protect individuals from abuse of the modern state's overwhelming power.
Only when those interests are protected can we then say that a culture should survive, not because the culture is intrinsically valuable, but rather because it has the uncoerced adherence of a sufficient number of persons.
These studies established that nanomolar amounts of TAT-AS protected against stress and increased Hsp70 protein levels, whereas micromolar amounts of the protein were intrinsically toxic to cells and decreased Hsp70 at the protein level.
Verlage, E. et al. A monolithically integrated, intrinsically safe, 10% efficient, solar-driven water-splitting system based on active, stable Earth-abundant electrocatalysts in conjunction with tandem III V light absorbers protected by amorphous TiO2 films.
Further studies should identify possible physiologically relevant basic and intrinsically disordered "gatekeepers" that can protect MBP from proteasome-mediated degradation.
Dehydrins are hydrophilic and highly flexible proteins (Intrinsically Unstructured Proteins, IUPs) that protect cytosolic and membrane proteins by wrapping around them [ 52] ('molecular-huggers').
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com