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Although the fluorescence-based bioassay was more sensitive, the technique was intrinsically compromised by the need for unknown ligands to cause fluorescence enhancement upon binding.
The reproducibility of dried droplet laser ablation is intrinsically compromised, compared to pneumatic nebulization, as a result of the additional error introduced by repeated droplet deposition and by the transient signal mode.
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During retinal tumorigenesis, miR-24 may intrinsically compromise the p53 response to RB1 loss.
A few survive the ordeal; most seem almost sadly compromised; others are intrinsically weak.
With the selection based only on the morphological characteristics after fertilization, seemingly appropriate but intrinsically handicapped embryos may be cultured and transferred resulting in compromised in vitro development, or low pregnancy rates, abortions and further negative consequences.
Siliceous grain boundary films readily corrode and compromise the intrinsically good corrosion resistance of bulk alumina.
Compromised repositories.
For intrinsically high-dimensional data, the only possible solution is to compromise and use approximate or probabilistic approaches.
However, these systems have also the potential to compromise the quality of health care if they are misused, intrinsically faulty or entail unexpected side effects.
Since the starting material is very limited and the reaction yield is intrinsically low, even losing a small fraction of the target DNA would potentially compromise sequencing efforts.
Or compromise.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com