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We evaluate how well this intrinsically acquired object knowledge can be used to solve externally specified tasks, including object recognition and achieving goals that require both planning and continuous control.
Comparative studies of extant and randomized sequences show that evolution enhances conformational order and diminishes conflicting molecular interactions over those intrinsically acquired by self-organization [25], [96] [102].
Although these cells may represent the most terminally differentiated T cells, suggesting that increased resistance to apoptosis is the outcome of senescence, a study investigating in vivo responses to activation induced cell death of T cells from aged mice implies age-related impairment of apoptosis can occur in previously unchallenged T cells and is perhaps intrinsically acquired [ 45].
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Several mechanisms of resistance to platinum compounds, either intrinsically or acquired, have been described.
Resistance to platinum-based chemotherapy is multifactorial, and exhibited either intrinsically or acquired with drug exposure.
This new class of sterically hindered platinum compound, selected for clinical trial in 1997, may therefore elicit improved clinical response in intrinsically and acquired cisplatin-resistant tumours in the clinic.
Taken together, these data strongly support the notion that whether intrinsically or acquired following paclitaxel (especially low concentration) treatment, the upregulation in BRCA1-IRIS in TNBC cells is a major obstacle against obtaining major efficacy for paclitaxel, especially in patients with metastatic breast cancer.
We hypothesized that PTK6 inhibition is an effective strategy to inhibit growth and survival of Her2+ breast cancer cells, including those that are relatively resistant to Lapatinib, a targeted therapy for Her2+ breast cancer, either intrinsically or acquired after continuous drug exposure.
The model, though not intrinsically contextual, acquires this quality upon post-selection of coincident detections.
The major cause of mortality in these patients can be attributed to cancers that are resistant to current therapies either intrinsically or through acquired mechanisms.
This raises the possibility that SP-G may be an effective anticancer agent in patients with neuropeptide-expressing tumours which are intrinsically resistant or have acquired resistance to conventional chemotherapy.
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