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Suggested filling schemes allow economical diagonal designs with intrinsic validation to be built for multiple factors presented in as many levels as the number of samples.
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As a result of this intrinsic self-validation, LDA has in practice proven to be exceptionally reliable.
This bootstrapping provides an intrinsic cross-validation which reduces the likelihood of over-fitting relative to more standard models [ 38, 42].
The intrinsic cross-validation is performed by constructing trees using different bootstrap sample groups of approximately one third the original data [ 22].
What will validation validate?
After extensive intrinsic and extrinsic validations, we harnessed MUTEA to derive mutation-rate estimates for 702 polymorphic STRs by tracing each locus over 222,000 meioses, resulting in the largest collection of Y-STR mutation rates to date.
In light of the large numbers of variables intrinsic to biomarker studies, validation of preliminary data for clinical implementation presents a significant challenge and may only be realized with large trials that involve significant patient numbers.
The validation of an intrinsic vulnerability map is always a challenging and complex task that needs caution to avoid any erroneous interpretations and misleading results.
The study revealed a high sensitivity of the system with respect to the modeling of intrinsic parameters, motivating a comprehensive validation of the estimates.
Integrating data from these new approaches into the study design and data analysis phases will require appropriate rigor of data and sample collection and validation that is intrinsic to the best epidemiologic and clinical research.
Conversely the limitations also provide some advantages in that our results are a stronger validation of the intrinsic value of the identified biomarkers because the biomarker diagnostic potential is preferably not limited to just certain assays.
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