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They allow intrinsic stabilization in knees with ligamentous instability.
Additionally, whether the Rad51 paralogs confer any intrinsic stabilization or alteration in the structural properties of the pre-synaptic complex is unknown, as is the mechanistic importance of their conserved Walker motifs.
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► New protocol allowing stabilization of proteins of already high intrinsic stability.
Thus, it is possible that the alternative cloverleaf model has a low intrinsic thermodynamic stability and can only be formed in vivo upon stabilization through interactions with other cellular or viral ligands or that the 5'- SL and/or the 3'- SL, but not the complete 4-helical junction, exist transiently in the folding intermediates to ensure the correct folding of RNA11.
Some of these proteins share conserved sites intrinsic to substrate recognition, structural stabilization and conformational changes.
Post-transcriptional regulation also plays an important role through RNA processing and stabilization to establish intrinsic circadian timing and clock-controlled output genes (see DOI: 10.1021/bi500707c).
Mutation of several interface residues of RGS4 affects catalysis indirectly by lowering the affinity between the proteins arguing that in both cases the stabilization of the intrinsic machinery by complex formation is the prevalent mechanism (Srinivasa et al, 1998).
Additionally, strategies based on heat incubation of surface displayed protein libraries for selection of stabilized variants are reported including a recently developed method that allows stabilization of proteins of already high intrinsic thermal stability like IgG1-Fc.
Convex theory allows us to reveal the intrinsic geometry involved in the clf stabilization problem, and to show that it is solvable if there is an optimal control ¯¯ω(x).
Photoluminescence (PL) and electron paramagnetic resonance (EPR) were used to show the importance of intrinsic sites of the support in stabilization of single-metal and alloyed Pd-containing clusters with high catalytic activity in CO oxidation.
Possible causes of regioselectivity in an enzyme include intrinsic reactivity, binding mode, and specific stabilization of key species in the enzyme.
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