► New protocol allowing stabilization of proteins of already high intrinsic stability.
These data clearly demonstrate the importance and efficacy of the presented strategy for selection of stabilizing mutations in proteins of high intrinsic stability within reasonable time.
Their low intrinsic stability in the lipid-free state likely facilitates interaction with lipid surfaces.
This intrinsic stability of IDH2 may contribute to observed inhibitor IDH1 isoform selectivity.
To investigate variability of tracer uptake, it was important to choose an organ, which can guarantee a certain intrinsic stability.
A tricortical opening wedge will provide intrinsic stability because of the tightening of the soft tissue (Fig. 12c).
For the distal radius nonunions, placement of an opening wedge will not only correct deformity but also provide intrinsic stability.
However, little has been understood about the intrinsic stability of their as-synthesized, high-entropy configurations against radiation damage.
Several antibody fragment engineering techniques aim at intrinsic stability enhancement, but are not applied in a truly generic way.
However, the low intrinsic stability and solubility of hGR-LBD have rendered its purification and biophysical characterization difficult.
Importantly, the supramolecular stabilized low-valent cobalt species remained fairly reactive towards aromatic halides despite its intrinsic stability.
