Our results suggested that OsRDR1 might play a role in maintaining the intrinsic locus-specific DNA methylation patterns, as its mutation caused alteration of methylation at some of the loci we analyzed.
These latter constraints can result either from nuclear determinants that organize chromatin at higher scales ("top-down" constraints) or from some intrinsic locus-specific components of the chromatin that are controlling genomic functions, like epigenetic modifications or the binding of specific factors ("bottom-up" constraints) [ 4].
Cells could also acquire mutator mutations that led to an increase in the cell's mutation rate: after M mutator mutations occurred in a single cell, the cell's intrinsic per-locus mutation rate increased from μ L to μ H mutations per division.
In this theory, the earth's biotic community per se is the sole locus of intrinsic value, whereas the value of its individual members is merely instrumental and dependent on their contribution to the "integrity, stability, and beauty" of the larger community.
On one well-studied yeast gene locus, PHO5, intrinsic properties of the promoter DNA were found to give nucleosome positions similar to those in vivo [ 65].
Additionally, we and others have recently shown that a large proportion of mutation rate variation at microsatellites can be explained by sequence features intrinsic to a microsatellite locus itself repeat number, motif size, and sequence (Kelkar et al. 2008).
The probability of a specific drug-resistant mutation arising will be a function of the intrinsic mutability of that locus and the number of proliferative 'at-risk' cycles in self-renewing cancer stem cells – the necessary repository of selectable mutations (Greaves, 2013).
MLVA was shown in a number of bacterial species to be capable of distinguishing closely related strains and successfully classifying more distant relationships [23] in spite of the intrinsic homoplasy of VNTR loci, at least when using the appropriate loci.
While some loci affect intrinsic susceptibility to LD, others modify the clinical form of the disease [ 6].
