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Our data demonstrate intrinsic developmental potential differences among ESC-derived precursor populations.
These environmental responses must intersect with the intrinsic developmental programme of the plant, which is responsible for the general formation and maintenance of the root system.
Intrinsic developmental growth programs can be reactivated in RGCs, neural activity can enhance RGC regeneration, and functional reformation of eye-to-brain connections is possible, even in the adult brain.
Integration of hormonal and other intrinsic developmental and environmental signals leads to changes in gene expression.
My collaborators and I believe that our studies are providing insight into the nature of normal brain development and the consequences of disrupting the partnership between intrinsic developmental mechanisms and early sensorimotor experience.
In autism, the underlying issue is that children do not intuitively grasp the social world -- which includes pragmatic language delays.Unlike those with ADHD, however, children with autism have an intrinsic developmental delay in a far wider array of social and communication skills.
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The proper development of the mammalian neocortex involves a balance between cell-intrinsic developmental programs and environmental factors.
Our finding that null mutations in CSN5 or Nedd8 caused two very distinct phenotypes of either under- or over-branching might suggest the existence of a certain threshold or switch in the intrinsic dendritic developmental program.
In each progressive stage of OL lineage maturation, we uncovered a range of unique REST and CoREST target genes encoding factors with roles in shaping early OL development as well as in regulating the intrinsic OL developmental rheostat that controls the fidelity of cell cycle exit and terminal differentiation including myelinlation (Table S4) [32].
That these relationships emerged consistently across a large sample of different genotypes agrees with the view that buffering and its genetic control may be an intrinsic property of developmental systems [9], [11].
However, the link between mitochondrial dysfunction, intrinsic apoptosis and developmental anomalies has not been demonstrated to date.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com