Sentence examples for intrinsic damage from inspiring English sources

As it was shown by Ritchie "the intrinsic damage processes that operate ahead of the tip of a crack to promote its propagation, and extrinsic crack-tip-shielding mechanisms that act mostly behind the crack tip to inhibit this propagation" [3].

As cells divide, their genome is under constant threat by intrinsic damage and exogenous agents that cause DNA lesions.

Work undertaken by our group has recently described a novel intrinsic damage repair response in mature equine articular cartilage explants following single impact load and subsequent culture [ 3].

Reduced telomerase levels as well as short telomeres are expected to compromise the number as well as the replicative potential of stem cells that remain in specific tissues after extrinsic or intrinsic damage from the environment.

These data thus support the concept that the mechanisms underlying the intrinsic damage signals in cyclin D1b-expressing lines are likely independent of major defects in DNA damage or cell cycle pathways.

For computational models of both extrinsic (ligand-induced) and intrinsic (damage-induced) apoptosis, strategies include Boolean or fuzzy logic, data-driven or Bayesian algorithms.

The onset of these processes allows the normal healthy cell and its transformed malignant variant to have an exaggerated apoptotic response to both intrinsic DNA damage and also to chemotherapy induced therapeutic DNA damage.

Obtained results indicate that the investigated binders did not completely recover their original fatigue resistance after rest time, confirming the existence of some intrinsic irreversible damage, the amount of which depends on the total damage experienced before load removal.

Although non-irradiated cells of some RC patients showed remarkably lower intrinsic DNA damage, i.e. in the range of controls, the mean value of background DNA damage (Fig.  1a) was significantly (p < 0.005) higher (0.5 ± 0.1 foci/nucleus) in the group of unselected RC patients, as compared to the group of healthy controls (0.1 ± 0.03).

DNA-damage response (DDR) promotes faithful transmission of genomes in dividing cells by reversing the extrinsic and intrinsic DNA damage, and is required for cell survival during replication.

In this context, we hypothesize that metastasis-associated protein 1 (MTan), an intrinsic DNA damage response component, possessing transient protective effect in primary spermatocytes against heat stress, bears the potential to be a diagnostic biomarker for the assessment of early testicular damage in varicoceles.