Sentence examples for intrinsic classification from inspiring English sources

The luminal subtypes are defined by high expression of approximately 80 genes within the intrinsic classification gene list including ESR1, GATA3, FOXA1, and c-Myb, the latter of which is a previously described proto-oncogene frequently observed as amplified in a variety of tumor types [7].

These proportions were consistent with the intrinsic classification of the Caucasian English tumors from dataset GSE22219 (Fig. S4, P = 0.525).

The transcriptomic intrinsic classification of breast cancer [ 10] has led to search for correlations between the Sorlie classes and specific genomic profiles.

(a) immunohistochemistry based on intrinsic classification, LA: luminal A, LB: luminal B, Her2: Her2-enriched; (b) TP53 mutation or immunohistochemical detection of p53 accumulation.

According to the gene expression-based intrinsic classification, breast carcinomas can be categorized into at least five subtypes: luminal A, luminal B, normal breast-like, human epidermal growth factor receptor 2 (Henrichediched, and a basal-like subtype [ 2, 3].

There was a correlation with the intrinsic classification although the basal tumors belong mainly to the G2I-2 group (Table 6) and with the Mib1 status suggesting a link with proliferation (Table 5).

Our goals were to (1) create a new breast tumor intrinsic list, (2) validate this list on an independent dataset to show the clinical significance of the "intrinsic" classifications, and (3) to derive an objective "intrinsic subtype" classifier that could be used clinically (see Figure 1 for overview of analyses performed).

Altogether, Perou intrinsic subtype classification and Pietenpol TNBC classification of PDX cohorts has the potential to further classify PDXs, identify novel treatment regimens, and facilitate appropriate patient selection for clinical trials.

This study validates the "breast tumor intrinsic" subtype classification as an objective means of tumor classification that should be translated into a clinical assay for further retrospective and prospective validation.

First, intrinsic subtype classification was performed using the PAM50 predictor of Parker and colleagues [ 21].

Intrinsic subtype classification was determined by PAM50 50-gene assay as described [ 18].