Exact(3)
Thus, the intrinsic assembly propensity of Ure2p prion domain into fibrils of amyloid nature appears to be abolished by its covalent association with the functional domain of the protein that leads to the generation of fibrils with high α-helical content.
Their exquisite NPC-typical sorting selectivity and strong intrinsic assembly propensity suggest that Nup98 FG phases can form in authentic NPCs and indeed account for the permeability properties of the pore.
Here is my hypothesis: eukaryotes enhance the intrinsic assembly features of the helical filament protein systems with two particular kinds of cytoskeleton-associated factors, which have not yet been found in bacteria.
Similar(57)
Intrinsic self-assembly, and higher-order assembly tightly modulated by aromatic compounds, provide insights into the formation of multilayer reflectors in iridophores and spherical microparticles in leucophores and may form the basis of structural color change in cephalopods.
These OEGylated CMPs show intrinsic supramolecular assembly behavior in solutions which was explored with UV/vis and CD spectroscopies, as well as dynamic light scattering.
Understanding how to guide the intrinsic self-assembly mechanisms of these cells may increase their regenerative efficacy and enable in situ tissue morphogenesis.
In developing tissues, however, in addition to the intrinsic self-assembly properties, there is cellular machinery that regulates fibril nucleation, spatial orientation, and fibril size, according to the tissue and stage of development.
This fact, along with the intrinsic self-assembly and outstanding material properties of amyloids, has prompted a significant amount of research in the synthetic design of functional amyloids to form diverse nanoarchitectures, molecular materials, and hybrid or composite materials.
In this way the lens, with its relatively simple cellular composition, serves as a useful model to highlight the importance of such intrinsic self-assembly mechanisms in tissue developmental and regenerative processes.
Their intrinsic self-assembly properties as well as their periodicity make S-layers ideal building blocks for all kinds of detection systems (DNA, protein or antibody chips as well as label-free detection systems) (for review see [ 10 ]).
Many areas of applied S-layer research will particularly be promoted by the construction of S-layer fusion proteins comprising the intrinsic self-assembly domain and a fused functional sequence (Table 2).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com