Diverse sources of MSCs include embryonic and extraembryonic lineages and adult tissues, such as bone, fat, and cartilage, each intricately regulated by specific signaling pathways.
As proteins levels and activities are intricately regulated, being able to take a high-resolution snapshot of cells' proteomes could ultimately allow better predictions of the states cells are in, provide new insights into their inner molecular workings, and reveal more accurate biomarkers and useful therapeutic targets for diseases.
This highly dynamic barrier is intricately regulated by myriad factors, including local oxygen tension, to both accommodate nutrient and fluid transport and exclude antigenic material [32].
The regulatory circuitry governing this normal balancing act is must be intricately regulated in normal homeostasis, and then transiently altered to cope with injury responses.
In summary, our results suggest that even though miRNAs are potentially exposed to the same cellular factors their biogenesis is individually and intricately regulated.
By contrast, the concurrent modulation of Stat3 and EGFR, or Stat3 and Src, or EGFR and Src strongly suppressed c-Myc expression, demonstrating that the novel nuclear heteromeric complex intricately regulates the c-Myc gene.
Angiogenesis is intricately regulated by stimulators and inhibitors.
Such intricately regulated operons allow functional differences depending on environmental conditions.
At the molecular level, LXRs function as ligand-activated transcription factors that intricately regulate and coordinate cholesterol homeostasis, glucose and lipid metabolism, and inflammatory signaling.
Eukaryotic cellular machineries are intricately regulated by several molecular mechanisms involving transcriptional control, post-translational control and post-translational modifications of proteins (PTMs).
