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Of these, the spliceosome is the largest and perhaps the most intricate, functioning to remove non-coding intronic sequence from multi-exon genes, which constitute the majority of genes expressed in higher eukaryotes (Jurica and Moore, 2003).
The ability to maintain one's stability is dependent on the intricate functioning of sensory, central integrative and musculoskeletal effector components (Thomas et al 2003).
27 It is also argued that prospective hazard analysis methods are necessary in order to develop a deeper understanding of the intricate functioning of the system and the identification of likely error producing conditions.
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A dialysis unit looks precise and powerful, but it can only approximate the intricate function of a human kidney.
Maintaining and regulating cardiac output, which is usually proportional to the tissues' need for oxygen and other nutrients, is one of the circulatory system's most intricate functions.
In contrast to classical organelles, podosomes are not vital at the cell level but rather serve diverse and often intricate functions of which adhesion, matrix degradation and substrate sensing are the most established.
It seems clear that the surgical approach used by McCormick and his colleagues could have severely disrupted the intricate function of the TPC.
In this study, we focused on the intricate functions of the immune system including complements especially in patients with end-stage renal disease.
Finally, the strong suspicion about the analogous and intricate functions of COG1518 and COG1343 (cf. page 21) could be similarly toned down.
Besides TGF-β1 function in controlling extracellular matrix components synthesis [ 53], our results provide important evidence that this cytokine performs a central and intricate function in the control of the ECM status by the modulation of MMPs, TIMPs and RECK expression.
Thus, a precise understanding of the origin of these cells and of the mechanisms involved in the regulation of their intricate functions are of paramount importance for the development of effective therapeutic approaches for the vast spectrum of disorders associated with tissue and organ fibrosis [ 5, 6].
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