His insistence on putting classical theory into practice in them has reinforced rather than weakened the effect of his gift of lively dialogue, robust characterization, and intricate, controlled plotting.
However, the mechanistic characterization of intricate TF-DNA interactions from first principles of biochemistry still remains elusive.
To somewhat simplify this intricate process, data-driven characterization of a complex system behavior often starts with defining a target set of system's distinct phenotypes of interest, such as thermo-resistance, acid-tolerance, hydrogen production, and enumerating only those key system components that could be responsible for or contributing to the given phenotype(s).
As scientists improved their characterization of the intricate physics of each device, they developed complex equations that took into account subtle effects that were not apparent from coarse laboratory measurements.
Further progress in the functional characterization of these intricate proteins, which probably have important roles in human cancer, should help us to improve human cancer diagnosis and prognosis, and to develop more effective therapeutic strategies.
The availability of high-throughput techniques for gene expression analysis and identification of promoter-transcription factor (TF) interactions has led to characterization of the intricate gene regulatory networks that govern organism behavior [ 1- 3].
Proteins involved in the recognition of viral infection have only recently been identified and the initial characterization of their roles in this intricate system is just now starting to be understood.
Characterization is important but complicated by the intricate structures, microheterogeneity, and the limitations of current tools for structural analysis.
Proper structural characterization can thus also be important to help understand such intricate relationships between different elements, as was shown to be the case for promoter regions and splice sites.
