Sentence examples for intricate alterations from inspiring English sources

Examples of tumor immune escape due to such intricate alterations of HLA phenotype have been described recently [ 16, 28].

Recent work has revealed the intricate alterations in histones, accompanied by the DNA damage response (DDR), which is necessary for facilitating signalling, checkpoints, and DNA repair.

As the pathogenesis of ACS is a complicated pathophysiological process accompanying intricate neuroendocrine alterations, 10 blood pressure level after myocardial infarction is a reflection of integrated cardiovascular system and neuroendocrine system.

Our studies reveal that axonal injury triggers an intricate sequence of alterations in axonal MT dynamics.

Firstly, while it is possible to produce CAD orthoses that require intricate and complex alterations to the shape and type, no single software package currently exists that would allow these to be made easily in a clinical setting.

[ 2- 4] The spectrum of histologic alterations during the intricate processes of multistep carcinogenesis can be classified as premalignant lesions, including low-grade and high-grade squamous intraepithelial lesions (SILs), and malignant invasive cervical cancers.

Although its role in the pathogenesis of NPC remains to be elucidated, the malignant transformation of EBV-infected nasopharyngeal epithelial cells is believed to be a multi-step process over a long period of time and involve an intricate interplay between EBV genes and host genetic alterations in premalignant nasopharyngeal epithelial cells [8]– [8]].

It is now clear that epigenetic events can occur at both the DNA level (i.e. DNA methylation) and chromatic level (i.e. histone modifications), resulting in an intricate process of interactions that ultimately lead to the alteration of gene expression [ 5- 7].

Alterations that occur in uremia profoundly disrupt this intricate system of regulation.

However, the intricate relationship that is observed between aerobic glycolysis and genetic alterations in cancer cells clearly points out that there exists a missing link between these two phenomena.

(DNA alteration, by the way, figures prominently in this movie's extravagantly intricate plot).