Sentence examples for intrauterine programming from inspiring English sources

Modification in antioxidant activity by maternal low protein diet could predispose to pancreatic islet dysfunction later in life and provide new insights to define a molecular mechanism responsible for intrauterine programming of endocrine pancreas.

Periconceptional folic acid use is associated with epigenetic changes in IGF2 in the child that may affect intrauterine programming of growth and development with consequences for health and disease throughout life.

Given the importance of intrauterine programming and BAT in energy balance, our findings implicate new roles for the lactogens in the interface between fetal and perinatal development and metabolic disease.

It has also been reported recently, that high folate intakes in vitamin B12 deficient mothers are shown to increase the risk of type 2 diabetes in the offspring suggesting that defects in one-carbon metabolism might be at the heart of intrauterine programming of adult disease [9].

An analysis of pathways affected suggests that intrauterine programming of UN animals to favor fat as an energy source results in mitochondrial dysfunction which initially affects the postnatal hepatic function and subsequently, via the resultant metabolic changes in other organs leads to the evolution of a phenotype similar to that of the metabolic syndrome.

We postulate that As might impair intrauterine programming and fetal neurodevelopment.

Both low birthweight and high birthweight have been associated with the development of cardiometabolic disease in adulthood, possibly reflecting the effect of intrauterine fetal programming.

The process of intrauterine epigenetic programming adjusted the developing fetuses to the situation of deficiency during the fetal period and early childhood life.

They suggested that intrauterine undernutrition programmed the fetus for diabetes.

Maternal obesity can also result in long-term health problems for the offspring, secondary to perinatal problems and to intrauterine and postnatal programming effects [ 7, 8], including an increased obesity risk in childhood and adulthood [ 9].

In another model of developmental programming, intrauterine growth restriction induced by uterine artery ligation in pregnant rats is associated with reduced expression of the Pdx1 gene in islets, also accompanied by altered histone modification state.