In the autoinhibited conformation, vinculin is unable to interact with binding partners due to intramolecular interactions between Vt and Vh.
In the absence of interaction with GTP-bound Rho, mDia1 and other DRFs are maintained in an autoinhibited state by intramolecular interactions between their C-terminal diaphanous autoregulatory domain (DAD) and the interacting region in the N-terminus, termed the DAD interacting domain (DID).
The partial X-ray structure of RNF125 revealed the presence of extensive intramolecular interactions between the RING and C2HC ZnF.
Our analysis reveals that intramolecular interactions between DBMs and eight-residue segments directly N-terminal to DBMs are the primary modulators of bZIP-bR helicities.
The chemical and morphologic details of polymers are described by a semiflexible chain model, which can be utilized to capture the intramolecular interactions between different segments.
The high level of performance of proteins and nucleic acids in terms of function is not only the result of their chemical (primary) structure but also of the implicit non-covalent intramolecular interactions between specific units in their sequence that promote folding into a well-defined (secondary and tertiary) three-dimensional structure.
However it has been shown in vitro that phosphopeptidic ligands of the SH2 domain are able to increase Src kinase activity by disrupting the intramolecular interactions between the Tyr521-phosphorylated C-terminal tail and the SH2 domain, thereby inducing a change from a "closed" inactive to an "open" active conformation of Src.
A ligand, 4-methoxy-4′,4″-bis[N,N-bis 2-pyridylmethyl) aminomethyl]triphenyl-amine, and its palladium and copper dinuclear complexes were designed and prepared in order to examine intramolecular interactions between an organic cation radical and the metal ion.
The intramolecular interactions between the different components of the molecule are thought to stabilise conformation.
Intramolecular interactions between the SH2 domain and tyrosine kinase domain are critical in regulation of catalytic activity.
where Vbonded defines the (intramolecular) interactions between atoms covalently bonded to each other, and Vnonbonded defines the intermolecular interactions.
