Sentence examples for intractable targets from inspiring English sources

By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved.

The Berkeley's SG center utilized several protein features including chain length and predicted transmembrane helices, coiled coils and low-complexity regions to eliminate the intractable targets (Chandonia et al., 2006).

English translators have employed several strategies against this intractable target.

Transmembrane proteins are intractable crystallization targets due to their low solubility and their substantial hydrophobic outer surfaces must be enclosed within a partial micelle composed of detergents to avoid aggregation.

The generally intractable multi-target Bayesian filter involves integrals of high dimensions.

Recent efforts toward drugging these 'undruggable' proteins have led to greatly increased focus on cell-penetrating mini-proteins as a new class of agents for targeting intractable intracellular proteins.

As a result, intractable affinity-tagged target proteins are often fused to small proteins such as NusA and SUMO to improve their solubility, expression, and stability [2].

However, because this study targeted intractable ITP that was non-responsive to corticosteroids, the platelet count would remain at <30 × 10/L even after corticosteroid administration.

Therein lies a key disadvantage of the cell-based lead-finding approach if an initial hit is chemically intractable and the target is not known, there may be no path forward.

Many protein and enzyme drug targets are intractable to the most sophisticated methods in structure-based drug design and discovery (SBDDD) in large part because a high degree of flexibility negates the use of one, or even a few, crystal structures in virtual screening or de novo design.

The development of new approaches to small-molecule library screening enables opportunity for compound discovery to target pharmacologically intractable proteins, such as transcription factors, and to modulate biological processes in the absence of knowledge of the target critical to the state switch.