Sentence examples for intractable target from inspiring English sources

English translators have employed several strategies against this intractable target.

By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved.

The Berkeley's SG center utilized several protein features including chain length and predicted transmembrane helices, coiled coils and low-complexity regions to eliminate the intractable targets (Chandonia et al., 2006).

The generally intractable multi-target Bayesian filter involves integrals of high dimensions.

Transmembrane proteins are intractable crystallization targets due to their low solubility and their substantial hydrophobic outer surfaces must be enclosed within a partial micelle composed of detergents to avoid aggregation.

As a result, intractable affinity-tagged target proteins are often fused to small proteins such as NusA and SUMO to improve their solubility, expression, and stability [2].

Therein lies a key disadvantage of the cell-based lead-finding approach if an initial hit is chemically intractable and the target is not known, there may be no path forward.

Recent efforts toward drugging these 'undruggable' proteins have led to greatly increased focus on cell-penetrating mini-proteins as a new class of agents for targeting intractable intracellular proteins.

However, because this study targeted intractable ITP that was non-responsive to corticosteroids, the platelet count would remain at <30 × 10/L even after corticosteroid administration.

The involvement of prostanoid receptors in broad areas of pathological phenomena has drawn much attention and explored their potential use as a therapeutic target in intractable diseases.

One class of cell-penetrating mini-proteins, all-hydrocarbon stapled peptides, has recently demonstrated the ability to potently and specifically target previously intractable proteins such as transcription factors, vaulting this class to the forefront of a new wave of next-generation drugs.