Additionally, one-step CNV-association testing, especially through complicated signal summarization, causes intractable results that cannot be compared to the primary data, whereas verification of association results from primary data is important in genome-wide association studies to provide the confidence for the findings by common consent.
Due to determining the optimal assignment and routing decisions of a large set of cargos transported by a ship fleet is inherently NP-hard, real-world problems are either intractable or result in poor solutions when solved with pure optimization approaches.
Although analytical work for SM using QAM becomes intractable, numerical results demonstrate that SM using a variable-amplitude modulation performs in a similar fashion to SM using PSK and leads to the same conclusions.
In both cases intractable mixtures resulted.
Both in patients with AoCLF and in those with otherwise well-compensated cirrhosis, MARS has been reported to be used with some success in the treatment of intractable pruritus resulting from intrahepatic cholestasis [ 25].
The explanation for this observation: Because the sensation of pain seems to be essential to the process of quelling itch, when the ability to feel pain is dampened by morphine and similar drugs, intractable itch may result.
As a result, intractable affinity-tagged target proteins are often fused to small proteins such as NusA and SUMO to improve their solubility, expression, and stability [2].
The importance of elucidating EpCAM function in vivo is highlighted by recent studies that demonstrate that at least some cases of congenital tufting enteropathy, a rare, typically autosomal recessive syndrome that is characterized by intractable infantile diarrhea, result from mutations in the gene encoding EpCAM [41].
Air-breathing hypersonic vehicles (HSVs) are typically characterized by interactions of elasticity, propulsion and rigid-body flight dynamics, which may result in intractable aeroservoelastic problem.
