"Cases are chosen primarily on the basis of their intractable course and their resistance to the usual procedures," Worthing explained.
The drug resistance of intractable epilepsy is also associated with MDR1 gene polymorphism.
But the forces feeding the resistance to change remain intractable.
The decline in Obama's political fortunes, the Great Disappointment, can be attributed to four main factors: the intractable legacy bequeathed by George W. Bush; Republican resistance amounting to sabotage; the unrealistic expectations and inevitable disenchantment of some of the president's supporters; and, to be sure, the man himself.
All KF-PDA-GO fibers not only have greatly improved surface activity and UV resistance, overcoming the two intractable disadvantages of KFs, but also show outstanding thermal resistance and higher tensile properties including tensile strength, modulus, elongation and break energy.
Although seemingly an intractable problem, the evolution of antibiotic resistance may represent a great opportunity.
American plans for a missile shield have stirred opposition in capitals across the globe, but China's resistance may be the most intractable.
In the present day context, when microbial antibiotic resistance is progressively morphing into an intractable predicament, acquisition of the potent PVL gene by MRSA, which represents a rather difficult challenge in itself, would pave the way to an alarming healthcare paradox.
It is clear that the peoples of Europe have a lot less experience than the Americans when it comes to living with those whose religion, skin colour, or cultural identity are different from their own, and that they do not warm to the prospect: this resistance makes Europe's internal problems all the more intractable.
Most of these tumors are characterized by diffuse infiltrative growth in the surrounding brain parenchyma which precludes curative treatment by surgery or radiotherapy alone, and together with their relative resistance towards conventional chemotherapy this places these tumors among the most intractable human malignancies [ 24].
