Distinct genetic features intractable to sequencing technologies, such as long arrays of tandem repeats were observed in the raw single molecules (Additional file 1: Figure S1).
Leveraging modern bioinformatic analytics against intricate stem cell transcriptome readouts can extract systems biology features intractable to other approaches, and demonstrates a novel capacity for stem cells as advanced high resolution diagnostic tools (Fig. 6).
Our patient presented with intractable infantile epilepsy (a feature never before reported in association with the 6p25 microdeletion syndrome) and a much smaller deletion than previously reported thereby prompting further investigation of the affected genes for a possible recessive aetiology.
Consistent neurological features of these disorders include intractable epilepsy, ID and autistic features, thus implicating these genes in epileptogenesis.
The malignant disorder, myeloma, is characterized by extensive bone destruction, which is manifested by a number of important clinical features including intractable bone pain, fractures that occur either spontaneously or following trivial injury, and hypercalcemia, which can be life-threatening.
However, clearly, the development of new DNA sequencing technologies might allow the discovery of features that were intractable with earlier techniques.
The proposed kernelized framework offers new opportunities to deal with non-Euclidean symmetries and to reconsider any intractable examples by means of implicit feature spaces.
Classification with thousands of classes and a large number of features is often computationally intractable.
The main features of DCC include intractable epilepsy, dementia, muscular enlargement, subcutaneous nodules and absence of focal neurological signs.
