He had spent much of his career working on some of the most intractable problems in development, and yet he also had experience managing large institutions.
By Elizabeth Kiem NEW YORK, USA, 15 January 2009 – UNICEF's flagship publication, 'The State of the World's Children 2009' – launched today in South Africa – addresses maternal mortality, one of the most intractable problems for development work.
In the early 1990s, the use of IOL in pediatric uveitic eyes was associated with significant inflammation, development of intractable glaucoma, cyclitic membrane, hypotony, and phthisis [37, 38].
Acute cardiac decompensation in LCR rats was exclusively due to the development of intractable irregular ventricular contractions.
Thus, hESCs provide a unique and powerful system to study otherwise intractable aspects of human development.
Typical symptoms are sensory and motor function defects that can result in complete paralysis of the affected limb or development of intractable neuropathic pain [ 4].
The proband (UDP1130; Fig. 1A) presented to the NIH Undiagnosed Diseases Program UDPP) 16– 18 at 6.5 years of age with a history of early-onset epileptic encephalopathy associated with profound cognitive impairment, absent motor development, and intractable seizures.
Rare mutations identified in DPAGT1 have been found to underlie a severe multisystems disorder [CDG1J (MIM 608093)] typically with delayed development, microcephaly, intractable seizures and learning difficulties (Marek et al., 1999; Wu et al., 2003; Wurde et al., 2012).
His subtle and unfussy reading of these intractable poems as the rhythmic development of theme and counter-theme effectively refutes the idea that they are just a ragbag.
