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Ironically, my answer here is no more than the answer that Koonin himself gives, i.e. we do not see intermediates because the intron catastrophe, and other nearly intractable consequences of a cell within a cell, made early eukaryogenesis a trying time.
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Optimal recovery of the synchronization parameters (timing, phase and frequency offsets) is analytically intractable and, as a consequence, most existing synchronization methods are either heuristic or based on approximate maximum likelihood (ML) arguments.
The impasse was portrayed as a doomsday machine that went off unexpectedly — the consequence of an intractable divide in Washington over taxes and spending.
He likened the consequences to the "tragic and intractable phenomenon which we watch with horror on the other side of the Atlantic," the 1968 race riots in America.
That Obama could not or would not elucidate his plans to address the intractable realities of race and the economic consequences of those realities, even as he acknowledged that "black unemployment has remained almost twice as high as white unemployment, Latino unemployment close behind," calls into question the logic of a black Presidency in itself.
That Obama could not — or would not — elucidate his plans to address the intractable realities of race and the economic consequences of those realities, even as he acknowledged that "black unemployment has remained almost twice as high as white unemployment, Latino unemployment close behind," calls into question the logic of a black Presidency in itself.
Social identities aligned with the communities of practice into which healthcare professionals have been socialised contribute to intractable identity conflicts 17 that may have severe consequences for implementing quality initiatives.
And that purely political choice turns a difficult situation into an intractable impasse – with 1,296 lives as its human consequence.
As a leader in the field of domestic violence, I recognize that, like many of today's most intractable social problems, human trafficking is often a consequence of violence in the home.
Consequently, practical solutions become quickly intractable.
The result pages are explicit and intractable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com