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The pro-Trump US rustbelt, and much of southern and eastern Europe, face similarly intractable brain drains.
(Google is known for hazing prospects in interviews with intractable brain teasers. And it once tried to attract candidates by placing some particularly difficult problems on billboards).
For the intractable brain diseases, the feasibility of immunotherapy and cell-based therapy have been studied using primates or small animals [1 3].
Design of a multifunctional MRI compatible NP platform provides a significant step forward for the diagnosis and treatment of intractable brain conditions, such as tinnitus.
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We consider the impact of mTORC2-related metabolism on epigenetics and therapeutics, with a particular focus on the intractable malignant brain tumor, glioblastoma multiforme (GBM).
Causes of death were classified in two categories: neurological causes (intractable seizures, brain herniation, cerebrovascular complications or coma) and systemic causes (septic shock, respiratory failure, disseminated intravascular coagulation or multiorgan dysfunction) [ 28].
These findings validate, a posteriori, the decision to carry out decompressive hemicraniectomy as a salvation therapy in life-threatening situations, in patients with intractable high ICP and brain herniation.
Recent findings from several groups including ours point to the epigenome as a previously under-appreciated hallmark of oncogenesis that drives several groups of intractable high-grade pediatric brain tumors.
Looking at 2020 and beyond, readers imagined a future with cures for intractable diseases, direct links between brain and computer, automated everything, contact with alien life forms, sentient machines and no language barriers.
In the present study, we report novel FARS2 mutations including a large scale genomic deletion, in a child with muscle-restricted OXPHOS deficiency associated with intractable infantile epilepsy and abnormal brain MRI findings.
Other brain malformations with intractable epilepsy are associated with SNVs in as few as 10% of cells assayed in blood or in brain (Gleeson et al., 2000; Jamuar et al., 2014; Kurek et al., 2012; Lee et al., 2012; Poduri et al., 2012, 2013).
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