A ketogenic diet (high fat, low carbohydrate) has been effective in patients with classical GLUT1 DS for management of intractable seizures and complex motor disorders, but had little effect on the cognitive impairment (De Vivo et al., 1991; Leary et al., 2003; Klepper et al., 2004).
Pyridoxine deficiency has been a consistent and unexpected finding among case-patients and controls tested, which is notable because of the known association between abnormal pyridoxine metabolism and complex, intractable seizures (37, 38 ).
Statistical inference provides an elegant framework to deal with this problem, but these methods are usually intended for single instrument f0 estimation (typically piano), as exact inference often becomes computationally intractable for complex and very different sources.
Primary care clinicians also felt they were having to cope with conflicting priorities and complex, sometimes intractable, needs.
The ability to conduct omics level experiments using only a few cells will allow researchers to answer questions that were previously intractable due to the heterogeneous and complex nature of most tissue samples.
The problem is that you are dealing with complex, intractable, and imponderable problems.
My day-to-day existence in Syria has largely consisted of witnessing an intractable, complex and seemingly hopeless sociological and ideological transition in slow motion.
However, the past two decades have seen these workers subject to more intractable response scenarios, including aid delivery in conflict and complex emergency settings.
Completion of an accurate assembly is a continuing challenge given the presence of multiple highly duplicated and complex regions that remain largely intractable to analysis with commonly used assembly techniques [ 1].
The situation is painful, complex and seemingly intractable, and into this lion's den, Kramer has willingly walked.
