Three non-linear parameters (H2O2 concentration, process temperature and time duration) those have intra relations were found to be significant that affects whiteness index in a constant pH (Haque and Islam 2015).
Relationships are the lifeblood of business and yet economies of scale, unbalanced by economies of scope, can degrade the inter- and intra-relations essential within and across organisational boundaries.
In this study, the entity of intra-relation or inter-relation is a patient.
We define the intra-relation as a graph constructed based on single genomic data alone such as gene expression data.
First, miRNAs and gene features were separately selected from the prediction model based on intra-relation using independent data set, miRNA expression and gene expression, respectively.
Data description and methods for prediction based on intra-relation among mRNAs and prediction based on inter-relation from miRNA to mRNA are explained in the Materials and Methods section.
In order to evaluate the effect of inter-relation betwee n miRNA and target genes, the intra-relation of gene expression was reconstructed from inter-relation between miRNA and gene expression.
In the present study, the intra-relation of gene expression was reconstructed from inter-relation between miRNA and gene expression for prediction of short-term/long-term survival of GBM patients.
However, intra-relations are not fully explaining complex cancer mechanisms because the inter-relation information between different levels of genomic data is missing, e.g. miRNA and its target genes.
There might be other possible intra-relations between different layers of genomic data such as 'copy number alteration region - genes located in the alteration region,'DNANA methylation site - specific genes regulated by promoter regions,' etc.
For all these modules the intra-module relations generally are stronger than the extra-module relations.
