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One might expect that the conservation scores would be lower for inter interactions than intra interactions, as an interface might show more "plasticity" than the core of a domain.
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Intra molecular interactions are found in between N3-H3a- - -O8 and C27-H27a- - -O6 [symmetry code a: (-x, 1-y,-z)] (Figure 8).
Multiple molecules of RRM-containing proteins bind to RNA oligonucleotides via inter and intra molecular interactions.
Most proteins (especially in the host) are likely to be involved in both inter and intra species interactions.
Because PKCε is regulated by multiple intra-molecular interactions, we reasoned that an inhibitory intra-molecular interaction may exist between the HSP90-binding site in PKCε and a sequence within PKCε that shares homology with a region on HSP90.
Simulations were performed in a broad temperature range and for intra-chain interactions varying from the fully interacting to the ideal spring chain.
We identified 57 intra-XLs, 42 of which were assigned to intra-Hsp40 interactions.
This model is in part supported by recent 3C analyses of intra-chromosomal interactions suggesting that several insulator sites can interact (A. Bushey, K. Van Bortle and V. Corces unpublished data).
The large proportion of observed intra-compartment interactions support that protein-protein interaction is a major driver for intra-nuclear organization.
"Fit-Hi-C takes renormalized data to identify mid-range intra-chromosomal interactions" --> "Fit-Hi-C takes normalizedatato to identify statistically significant intra-chromosomal interactions".
Our results reveal important inter- and intra-subunit interactions of residues in the Trp-motif.
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