One might expect that the conservation scores would be lower for inter interactions than intra interactions, as an interface might show more "plasticity" than the core of a domain.
Specifically, intra-molecular interactions and interactions involving proteins that require numerous cofactors or chaperones to fold properly are difficult or impossible to analyze by these methods.
Because PKCε is regulated by multiple intra-molecular interactions, we reasoned that an inhibitory intra-molecular interaction may exist between the HSP90-binding site in PKCε and a sequence within PKCε that shares homology with a region on HSP90.
We show how such peaks may arise from input and are stabilized by intra-field interaction.
We attribute the deformation phase transitions to the interplay of inter-wall and intra-wall interaction energies.
Intra molecular interactions are found in between N3-H3a- - -O8 and C27-H27a- - -O6 [symmetry code a: (-x, 1-y,-z)] (Figure 8).
Given that conformer models are produced in vacuum, is it beneficial to remove bias towards conformers with intra-molecular interaction to improve accuracy?
The MuHV-4 gB and gH associate constitutively and independently of gL, probably via an intra-membrane interaction [21].
These results suggest that the TORC1-PP2A pathway mediates nuclear translocation of Cdc5 via regulation of its intra-molecular interaction.
The intra-molecular interaction between the kinase domain and the PBD might thus inhibit nuclear import, recruitment to the target sites, and kinase activity.
Furthermore, the trials demonstrated that on-shark tags can provide important inter- and intra-specific interaction data among individuals in areas remote from traditional fixed receiver arrays [19].
