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Whole process consists of obtaining potential hubs, finding optimum location of hubs and allocation of non-hub nodes to hub nodes, generating inter hub and intra-hub routes and the frequencies for running buses.
In an intra-national "hub and spoke" flight network in which direct flights to the capital are unavailable, demand for transport to the local airport can leak to car transport for the trip to the central airport [17].
Consideration of the 55 intra-module hub genes from critical regulatory modules revealed a number of signaling and cellular processes were influenced, Figure 5 and Figure S3.
Fraser extended the study in view of the modularity, and revealed that the intra-module hub genes evolve more slowly than the inter-module ones in a yeast protein-protein interactome [31].
Here we focused on intra-modular hub proteins which has high clustering coefficient [ 21].
Likewise, intra-modular hubs of the highest connectivity for each stage of comparison were also listed in Table 3. Top 10 enriched canonical pathways resulted from the IPA analysis using the verified gene lists were quite different from those using the full gene lists.
In Figure 3d, we show a subset of the entire network using the top 10% probesets with the highest intra-modular connectivity (hub nodes).
This is very different from patterns in South Africa, which attracts migrants from elsewhere in Africa but is also an important source of emigration out of the continent, highlighting its major role as a hub linking intra- and extra-African migration.
The mTOR pathway is a central signaling hub that integrates intra- and extracellular signals to control processes related to cell growth and metabolism.
In our identified MAOCs, we picked up 4 hub genes, 5 intra-MAOC genes and 5 inter-MAOC genes, where the intra-MAOC genes are those inside one module and have interactions with genes belonging to other modules while the inter-MAOC genes are those outside of MAOCs but have interactions with genes belonging to MAOCs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com